Increased platelet membrane phosphatidylinositol-4,5-bisphosphate in drug-free depressed bipolar patients

被引:25
作者
Soares, JC
Dippold, CS
Wells, KF
Frank, E
Kupfer, DJ
Mallinger, AG
机构
[1] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA
[3] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA
[4] Univ Pittsburgh, Sch Med, Dept Pharmacol, Pittsburgh, PA 15261 USA
关键词
phosphoinositide; platelet; bipolar disorder; affective disorders; signal transduction; second messenger; pathophysiology;
D O I
10.1016/S0304-3940(00)01775-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Prior investigations in bipolar disorder patients have suggested abnormalities in the cellular phosphoinositide second messenger system. This study was conducted to examine the levels of platelet membrane phosphoinositides in drug-free bipolar patients in the depressed state (n = 9) and healthy controls (n = 19). Bipolar patients had significantly increased levels of platelet membrane phosphatidylinositol-4,5-bisphosphate (PIP2) compared to healthy individuals (0.67 +/- 0.14 and 0.44 +/- 0.17%, respectively, t-test = 3.71, d.f. = 26, P = 0.001). No significant differences in the levels of phosphatidylinositol-4-phosphate (PIP) (0.65 +/- 0.17 and 0.58 +/- 0.20%, respectively, t-test = 1.02; d.f. = 26; P = 0.32) or phosphatidylinositol (PI) (5.92 +/- 1.23 and 5.56 +/- 1.45%, respectively, t-test = 0.68; d.f. = 26; P = 0.51) were found. These findings provide the first demonstration of increased PIP2 platelet levels in bipolar patients in the depressed state, and provide additional evidence that the phosphoinositide second messenger system may be a site of abnormality in bipolar disorder. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:150 / 152
页数:3
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