Effect of the herbicide glyphosate on enzymatic activity in pregnant rats and their fetuses

被引：86

作者：

Daruich, J ^{[1
]}

Zirulnik, F ^{[1
]}

Gimenez, MS ^{[1
]}

机构：

[1] Univ Nacl San Luis, Fac Quim Bioquim & Farm, Area Quim Biol, Catedra Bioquim Mol, RA-5700 San Luis, Argentina

来源：

ENVIRONMENTAL RESEARCH | 2001年 / 85卷 / 03期

关键词：

glyphosate; dehydrogenases; pregnancy; fetuses;

D O I：

10.1006/enrs.2000.4229

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

To prevent health risk from environmental chemicals, particularly for progeny, we have studied the effects of the herbicide glyphosate on several enzymes of pregnant rats. Glyphosate is an organo-phosphorated nonselective agrochemical widely used in many countries including Argentina and acts after the sprout in a systemic way. We have studied three cytosolic enzymes: isocitrate dehydrogenase-NADP dependent, glucose-6-phosphate dehydrogenase, and malic dehydrogenase in liver, heart, and brain of pregnant Wistar rats. The treatment was administered during the 21 days of pregnancy, with 1 week as an acclimation period. The results suggest that maternal exposure to agrochemicals during pregnancy induces a variety of functional abnormalities in the specific activity of the enzymes in the studied organs of the pregnant rats and their fetuses. 2001 Academic Press.

引用

页码：226 / 231

页数：6

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