Artemisinins and the biological basis for the PfATP6/SERCA hypothesis

被引：50

作者：

Krishna, Sanjeev ^{[1
]}

Pulcini, Serena ^{[1
]}

Fatih, Farrah ^{[1
]}

Staines, Henry ^{[1
]}

机构：

[1] St Georges Univ London, Ctr Infect Cellular & Mol Med, London SW17 0RE, England

来源：

TRENDS IN PARASITOLOGY | 2010年 / 26卷 / 11期

基金：

英国惠康基金;

关键词：

PLASMODIUM-FALCIPARUM MALARIA; POLYMERASE-CHAIN-REACTION; GENE COPY NUMBER; DIHYDROFOLATE-REDUCTASE; APICOMPLEXAN PARASITES; CALCIUM REGULATION; TOXOPLASMA-GONDII; DRUG-RESISTANCE; POINT MUTATIONS; PYRIMETHAMINE;

D O I：

10.1016/j.pt.2010.06.014

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

With the advent of artemisinin resistance it is timely to revisit the biological basis for the controversial suggestion that this class of antimalarial exerts its activity by inhibiting a calcium ATPase (PfATP6) that is most similar to sarcoplasmic endoplasmic reticulum calcium ATPases (SERCAs) Herein, evidence is discussed that relates to this hypothesis as alternative suggestions for how artemisinins might act have been reviewed elsewhere

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收藏

页码：517 / 523

页数：7

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