Presynaptic localization of a metabotropic glutamate receptor, mGluR4a, in the cerebellar cortex: A light and electron microscope study in the rat

被引：72

作者：

Kinoshita, A

Ohishi, H

Nomura, S

Shigemoto, R

Nakanishi, S

Mizuno, N

机构：

[1] KYOTO UNIV,FAC MED,DEPT MORPHOL BRAIN SCI,KYOTO 60601,JAPAN

[2] KYOTO UNIV,FAC MED,DEPT BIOL SCI,KYOTO 60601,JAPAN

[3] KYOTO UNIV,COLL MED TECHNOL,KYOTO 60601,JAPAN

[4] KYOTO UNIV,FAC MED,DEPT NEUROL,KYOTO 60601,JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 207卷 / 03期

关键词：

metabotropic glutamate receptor; mGluR4; cerebellum; granule cells; parallel fibers; antibody; immunohistochemistry; L-2-amino-4-phosphonobutyrate;

D O I：

10.1016/0304-3940(96)12519-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Localization of a metabotropic glutamate receptor, mGluR4a, was immunohistochemically examined in the rat cerebellum with an antibody, which was produced by using a synthetic peptide corresponding to a C-terminal sequence of rat mGluR4a. Marked mGluR4a-like immunoreactivity (mGluR4a-LI) was seen in neuropil of the molecular layer of the cerebellar cortex. Electron microscopically, mGluR4a-LI was observed in many axon terminals in the molecular layer. These axon terminals showing mGluRLFa-LI were filled with round synaptic vesicles and were in asymmetric synaptic contacts most frequently with dendritic spines. The results indicate that mGluR4a are located presynaptically in the parallel fibers arising from the granule cells in the cerebellar cortex.

引用

页码：199 / 202

页数：4

共 20 条

[1] EXPRESSION OF MESSENGER-RNAS OF L-AP4-SENSITIVE METABOTROPIC GLUTAMATE RECEPTORS (MGLUR4, MGLUR6, MGLUR7) IN THE RAT RETINA [J].