HtrA2/Omi, a sheep in wolf's clothing

被引：38

作者：

Vaux, DL ^{[1
]}

Silke, J ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

CELL | 2003年 / 115卷 / 03期

关键词：

D O I：

10.1016/S0092-8674(03)00851-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian mitochondrial HtrA2/Omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant HtrA2/Omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded proteins in the mitochondria.

引用

页码：251 / 253

页数：3

共 8 条

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