Mammalian mitochondrial IAP binding proteins

被引：192

作者：

Vaux, DL ^{[1
]}

Silke, J ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 304卷 / 03期

基金：

英国医学研究理事会;

关键词：

Diablo; Smac; HtrA2; Omi; IAP; caspase; reaper; grim; HID;

D O I：

10.1016/S0006-291X(03)00622-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four mitochondrial proteins have been identified that immunoprecipitate with the mammalian inhibitor of apoptosis (IAP) protein XIAP. Each of them interacts via a processed amino terminus that resembles those of the insect pro-apoptotic TAP binding proteins Grim, HID, Reaper, and Sickle. Two, Diablo/Smac and HrtA2/Omi, have been extensively characterized. Both Diablo and HtrA2 can bind to IAPs and promote apoptosis when over-expressed in transfected cells, but unlike the insect IAP antagonists, to date there is scant evidence that they are important regulators of apoptosis in more physiological circumstances. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：499 / 504

页数：6

共 66 条

[1]

ARNL CR, 2002, J BIOL CHEM, V277, P44236

[2] Structural basis of caspase-7 inhibition by XIAP [J].

Chai, JJ ;

Shiozaki, E ;

Srinivasula, SM ;

Wu, Q ;

Dataa, P ;

Alnemri, ES ;

Shi, YG .

CELL, 2001, 104 (05) :769-780

[3] Structural and biochemical basis of apoptotic activation by Smac/DIABLO [J].

Chai, JJ ;

Du, CY ;

Wu, JW ;

Kyin, S ;

Wang, XD ;

Shi, YG .

NATURE, 2000, 406 (6798) :855-862

[4] grim, a novel cell death gene in Drosophila [J].

Chen, P ;

Nordstrom, W ;

Gish, B ;

Abrams, JM .

GENES & DEVELOPMENT, 1996, 10 (14) :1773-1782

[5] The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid [J].

Christich, A ;

Kauppila, S ;

Chen, P ;

Sogame, N ;

Ho, SI ;

Abrams, JM .

CURRENT BIOLOGY, 2002, 12 (02) :137-140

[6] The HtrA family of proteases: Implications for protein composition and cell fate [J].

Clausen, T ;

Southan, C ;

Ehrmann, M .

MOLECULAR CELL, 2002, 10 (03) :443-455

[7] Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation [J].

Conte, D ;

Liston, P ;

Wong, JW ;

Wright, KE ;

Korneluk, RG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (09) :5049-5054

[8] AN APOPTOSIS-INHIBITING BACULOVIRUS GENE WITH A ZINC FINGER-LIKE MOTIF [J].

CROOK, NE ;

CLEM, RJ ;

MILLER, LK .

JOURNAL OF VIROLOGY, 1993, 67 (04) :2168-2174

[9] HtrA - A renaissance protein [J].

Day, CL ;

Hinds, MG .

STRUCTURE, 2002, 10 (06) :737-739

[10] IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases [J].

Deveraux, QL ;

Roy, N ;

Stennicke, HR ;

Van Arsdale, T ;

Zhou, Q ;

Srinivasula, SM ;

Alnemri, ES ;

Salvesen, GS ;

Reed, JC .

EMBO JOURNAL, 1998, 17 (08) :2215-2223

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