Mammalian mitochondrial IAP binding proteins

被引:192
作者
Vaux, DL [1 ]
Silke, J [1 ]
机构
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
基金
英国医学研究理事会;
关键词
Diablo; Smac; HtrA2; Omi; IAP; caspase; reaper; grim; HID;
D O I
10.1016/S0006-291X(03)00622-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Four mitochondrial proteins have been identified that immunoprecipitate with the mammalian inhibitor of apoptosis (IAP) protein XIAP. Each of them interacts via a processed amino terminus that resembles those of the insect pro-apoptotic TAP binding proteins Grim, HID, Reaper, and Sickle. Two, Diablo/Smac and HrtA2/Omi, have been extensively characterized. Both Diablo and HtrA2 can bind to IAPs and promote apoptosis when over-expressed in transfected cells, but unlike the insect IAP antagonists, to date there is scant evidence that they are important regulators of apoptosis in more physiological circumstances. (C) 2003 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:499 / 504
页数:6
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