Enantioselective Pd-catalyzed allylic amination with self-assembling and non-assembling monodentate phosphine ligands

被引：38

作者：

Birkholz, Mandy-Nicole

Dubrovina, Natalia V.

Shuklov, Ivan A.

Holz, Jens

Paciello, Rocco

Waloch, Christoph

Breit, Bernhard ^{[1
]}

Boerner, Armin

机构：

[1] Univ Freiburg, Inst Organ Chem & Biochem, D-79104 Freiburg, Germany

[2] Univ Rostock e V, Leibniz Inst Katalyse, D-18059 Rostock, Germany

[3] BASF AG, GCB O M313, D-67059 Ludwigshafen, Germany

[4] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 17期

关键词：

D O I：

10.1016/j.tetasy.2007.08.026

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New chiral phospholanes were prepared by coupling of bromo-substituted heterocycles with the enantiopure, building block (2R,5R)-2,5-dimethyl-1-chlorophospholane. Some of the new phosphine ligands have the potential for self-assembling via hydrogen bondings in a metal complex. By application of these and related ligands in the palladium catalyzed allylic amination reaction, high enantioselectivities (up to 99%) were achieved. The influence of the construction of the cyclic phosphine ligands on the en antioselectivity is analyzed. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2055 / 2060

页数：6

共 33 条

[31] A MODEL FOR METAL-TEMPLATED CATALYTIC ASYMMETRIC INDUCTION VIA PI-ALLYL FRAGMENTS [J].