Priming with L-DOPA differently affects dynorphin and substance P mRNA levels in the striatum of 6-hydroxydopamine-lesioned rats after challenge with dopamine D1-receptor agonist

被引：22

作者：

van de Witte, SV

Drukarch, B

Stoof, JC

Voorn, P

机构：

[1] Free Univ Amsterdam, Neurosci Res Inst, Dept Anat Embryol, NL-1081 BT Amsterdam, Netherlands

[2] Free Univ Amsterdam, Neurosci Res Inst, Dept Neurol, NL-1081 BT Amsterdam, Netherlands

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 61卷 / 1-2期

关键词：

6-hydroxydopamine; dopamine receptor; basal ganglia; sensitization; turning behavior; in situ hybridization;

D O I：

10.1016/S0169-328X(98)00214-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In unilaterally 6-hydroxydopamine-lesioned rats, potentiation of D1-agonist-induced turning behavior by priming with L-DOPA was correlated with changes in striatal neuropeptide mRNA levels. In non-primed rats, administration of the D1-agonist SKF-38393 markedly increased dynorphin and substance P mRNA levels in the lesioned striatum. Priming with L-DOPA dissociated the response of the two neuropeptides to the D1-agonist, with higher dynorphin and reduced substance P mRNA levels. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：219 / 223

页数：5

共 22 条

[1] FUNCTIONAL ARCHITECTURE OF BASAL GANGLIA CIRCUITS - NEURAL SUBSTRATES OF PARALLEL PROCESSING
ALEXANDER, GE
CRUTCHER, MD
[J]. TRENDS IN NEUROSCIENCES, 1990, 13 (07) : 266 - 271
[2] PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX
ALEXANDER, GE
DELONG, MR
STRICK, PL
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 : 357 - 381
[3] Induction of dopamine D-3 receptor expression as a mechanism of behavioral sensitization to levodopa
Bordet, R
Ridray, S
Carbon, S
Diaz, J
Sokoloff, P
Schwartz, JC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (07) : 3363 - 3367
[4] CHRONIC L-DOPA TREATMENT IN THE UNILATERAL 6-OHDA RAT - EVIDENCE FOR BEHAVIORAL SENSITIZATION AND BIOCHEMICAL TOLERANCE
CAREY, RJ
[J]. BRAIN RESEARCH, 1991, 568 (1-2) : 205 - 214
[5] EARLY L-DOPA TREATMENT INITIALLY RETARDS BUT LATER ENHANCES DOPAMINE-RECEPTOR SUPERSENSITIVITY FOLLOWING UNILATERAL DOPAMINE DENERVATION
CAREY, RJ
PINHEIROCARRERA, M
TOMAZ, C
HUSTON, JP
[J]. BRAIN RESEARCH, 1994, 658 (1-2) : 145 - 154
[6] SEQUENCE AND EXPRESSION OF THE RAT PRODYNORPHIN GENE
CIVELLI, O
DOUGLASS, J
GOLDSTEIN, A
HERBERT, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (12) : 4291 - 4295
[7] CONTINUOUS AND INTERMITTENT LEVODOPA DIFFERENTIALLY AFFECT ROTATION INDUCED BY D-1 AND D-2 DOPAMINE AGONISTS
ENGBER, TM
SUSEL, Z
JUNCOS, JL
CHASE, TN
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 168 (03) : 291 - 298
[8] LEVODOPA REPLACEMENT THERAPY ALTERS ENZYME-ACTIVITIES IN STRIATUM AND NEUROPEPTIDE CONTENT IN STRIATAL OUTPUT REGIONS OF 6-HYDROXYDOPAMINE LESIONED RATS
ENGBER, TM
SUSEL, Z
KUO, S
GERFEN, CR
CHASE, TN
[J]. BRAIN RESEARCH, 1991, 552 (01) : 113 - 118
[9] D1 AND D2 DOPAMINE RECEPTOR REGULATED GENE-EXPRESSION OF STRIATONIGRAL AND STRIATOPALLIDAL NEURONS
GERFEN, CR
ENGBER, TM
MAHAN, LC
SUSEL, Z
CHASE, TN
MONSMA, FJ
SIBLEY, DR
[J]. SCIENCE, 1990, 250 (4986) : 1429 - 1432
[10] GERFEN CR, 1992, ANNU REV NEUROSCI, V15, P285, DOI 10.1146/annurev.ne.15.030192.001441

← 1 2 3 →