Lack of association between two polymorphisms of brain-derived neurotrophic factor and response to typical neuroleptics

被引：47

作者：

Anttila, S ^{[1
]}

Illi, A

Kampman, O

Mattila, KM

Lehtimäki, T

Leinonen, E

机构：

[1] Tampere Univ Hosp, Dept Psychiat, FIN-33380 Pitkaniemi, Finland

[2] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland

[3] Kanta Hame Cent Hosp, Dept Psychiat, Hameenlinna, Finland

[4] Seinajoki Hosp Dist, Dept Psychiat, Seinajoki, Finland

[5] Tampere Univ Hosp, Ctr Lab Med, Lab Atherosclerosis Genet, Dept Clin Chem, Tampere, Finland

来源：

JOURNAL OF NEURAL TRANSMISSION | 2005年 / 112卷 / 07期

关键词：

BDNF; polymorphism; schizophrenia; pharmacogenetic study; age at onset;

D O I：

10.1007/s00702-004-0233-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Several studies have connected brain-derived neurotrophic factor (BDNF) with treatment response to neuroleptics. In recent studies, the BDNF expression was reduced by typical neuroleptics. We conducted a retrospective study on 94 patients with schizophrenia and 98 controls. The BDNF G196A and C270T polymorphisms are not associated with treatment response to typical neuroleptics or with age at first hospitalization. Moreover, these polymorphisms of the BDNF gene are not associated with the risk of schizophrenia.

引用

页码：885 / 890

页数：6

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