An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients

被引:116
作者
Hong, CJ
Yu, YWY
Lin, CH
Tsai, SJ
机构
[1] Taipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan
[3] Yus Psychiat Clin, Kaohsiung, Taiwan
[4] Kai Suan Psychiat Hosp, Kaohsiung, Taiwan
关键词
brain-derived neurotrophic factor; schizophrenia; polymorphism; clozapine; treatment response;
D O I
10.1016/S0304-3940(03)00828-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A growing body of evidence suggests the involvement of brain-derived neurotrophic factor (BDNF) in both antipsychotic action and schizophrenia pathogenesis. The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with schizophrenia and clozapine's therapeutic response. To identify any genetic predisposition to schizophrenia, we studied the BDNF-gene Val66Met polymorphism in 93 schizophrenic patients and 198 normal controls. Statistical analysis was used to test the association between this polymorphism and clozapine response the schizophrenic group. A trend (P = 0.055) was demonstrated between genetic predisposition and Val66Met genotypes in 93 schizophrenic patients, especially for those with good response to clozapine (P = 0.023). No significant difference in clozapine therapeutic response was demonstrated comparing the three Val66Met-genotype subgroups. Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment. (C) 2003 Published by Elsevier Ireland Ltd.
引用
收藏
页码:206 / 208
页数:3
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