Argatroban: A synthetic thrombin inhibitor of low relative molecular mass

被引：39

作者：

Fitzgerald, D ^{[1
]}

Murphy, N ^{[1
]}

机构：

[1] ROYAL COLL SURGEONS IRELAND, CTR CARDIOVASC SCI, DUBLIN, IRELAND

来源：

CORONARY ARTERY DISEASE | 1996年 / 7卷 / 06期

基金：

英国惠康基金;

关键词：

thrombin; thrombin inhibitor; argatroban; thrombosis;

D O I：

10.1097/00019501-199606000-00008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Argatroban is an arginine derivative that is a highly specific thrombin inhibitor. Experimentally, it is more effective than heparin but it is not known whether this is the case in humans. The trials reported with argatroban to date have been too small to define either the efficacy or the safety of the drug. Large-scale clinical trials are under way in a variety of settings, including unstable angina, coronary angioplasty and acute myocardial infarction.

引用

页码：455 / 458

页数：4

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