Electrochemical DNA sensors for detection of DNA damage

被引：117

作者：

Diculescu, VC ^{[1
]}

Paquim, AMC ^{[1
]}

Brett, AMO ^{[1
]}

机构：

[1] Univ Coimbra, Fac Ciencias & Tecnol, Dept Quim, P-3004535 Coimbra, Portugal

来源：

SENSORS | 2005年 / 5卷 / 6-10期

关键词：

DNA-electrochemical biosensor; DNA damage; damage to DNA bases; oxidative stress; biomarker of DNA damage; 8-oxo-7,8-dihydroxguanine (8-oxoGua); 8-oxo-7,8-dihydro-2 '-deoxyguanosine (8-oxodGuo);

D O I：

10.3390/s5060377

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Electrochemical devices have received particular attention due to their rapid detection and great sensitivity for the evaluation of DNA-hazard compounds interaction mechanisms. Several types of bioanalytical method use nucleic acids probes to detect DNA damage. This article reviews current directions and strategies in the development and applications of electrochemical DNA sensors for the detection of DNA damage.

引用

页码：377 / 393

页数：17

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