New acetylenic furan derivatives:: synthesis and anti-inflammatory activity

被引：62

作者：

Zeni, G ^{[1
]}

Lüdtke, DS

Nogueira, CW

Panatieri, RB

Braga, AL

Silveira, CC

Stefani, HA

Rocha, JBT

机构：

[1] UFSM, Dept Quim, Lab Bioquim Toxicol, BR-97105900 Santa Maria, RS, Brazil

[2] USP, Fac Ciencias Farmaceut, Sao Paulo, Brazil

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(01)01984-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of acetylenic furan derivatives have been synthesized via Pd-catalyzed coupling reactions of 2-(alkyltel-luro)furan with several terminal alkynes. These compounds showed good anti-inflammatory activity in the carrageenin-induced rat paw edema assay. This represents a new and efficient method for the synthesis of pharmacologically active compounds. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8927 / 8930

页数：4

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