Do sex and race/ethnicity influence CD4 cell response in patients who achieve virologic suppression during antiretroviral therapy?

被引:37
作者
Giordano, TP
Wright, JA
Hasan, MQ
White, AC
Graviss, EA
Visnegarwala, F
机构
[1] Baylor Coll Med, Dept Med, Infect Dis Sect, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Med, Sect Hlth Serv Res, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
关键词
D O I
10.1086/376638
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To determine whether CD4 cell count response to virus suppression during highly active antiretroviral therapy differs according to sex or race/ethnicity, we analyzed data in our observational cohort study for patients receiving their first antiretroviral regimen who experienced virus suppression by 6 months of therapy. In both univariate and multivariate analyses, women had greater CD4 cell count increases, compared with men, as did patients receiving a regimen that did not include a protease inhibitor. Race/ethnicity was not a factor.
引用
收藏
页码:433 / 437
页数:5
相关论文
共 24 条
[1]   Risk of progression to AIDS and death in women infected with HIV-1 initiating highly active antiretroviral treatment at different stages of disease [J].
Anastos, K ;
Barrón, Y ;
Miotti, P ;
Weiser, B ;
Young, M ;
Hessol, N ;
Greenblatt, RM ;
Cohen, M ;
Augenbraun, M ;
Levine, A ;
Muñoz, A .
ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (17) :1973-1980
[2]   Female sex and the use of anti-allergic agents increase the risk of developing cutaneous rash associated with nevirapine therapy [J].
Antinori, A ;
Baldini, F ;
Girardi, E ;
Cingolani, A ;
Zaccarelli, M ;
Di Giambenedetto, S ;
Barracchini, A ;
De Longis, P ;
Murri, R ;
Tozzi, V ;
Ammassari, A ;
Rizzo, MG ;
Ippolito, G ;
De Luca, A .
AIDS, 2001, 15 (12) :1579-1581
[3]   Baseline predictors of CD4 T-lymphocyte recovery with combination antiretroviral therapy [J].
Bennett, KK ;
DeGruttola, VG ;
Marschner, IC ;
Havlir, DV ;
Richman, DD .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2002, 31 (01) :20-26
[4]   Sex differences in nevirapine rash [J].
Bersoff-Matcha, SJ ;
Miller, WC ;
Aberg, JA ;
van der Horst, C ;
Hamrick, HJ ;
Powderly, WG ;
Mundy, LM .
CLINICAL INFECTIOUS DISEASES, 2001, 32 (01) :124-129
[5]  
Centers for Disease Control and Prevention, 2001, HIV AIDS SURVEILLANC, V13, P1
[6]   Long-term outcomes among antiretroviral-naive human immunodeficiency virus-infected patients with small increases in CD4+ cell counts after successful virologic suppression [J].
Dronda, F ;
Moreno, S ;
Moreno, A ;
Casado, JL ;
Pérez-Elías, MJ ;
Antela, A .
CLINICAL INFECTIOUS DISEASES, 2002, 35 (08) :1005-1009
[7]  
FINKEL D, 2001, 39 ANN M INF DIS SOC
[8]   Response to first protease inhibitor- and efavirenz-containing antiretroviral combination therapy - The Swiss HIV Cohort Study [J].
Friedl, AC ;
Ledergerber, B ;
Flepp, M ;
Hirschel, B ;
Telenti, A ;
Furrer, H ;
Bucher, HC ;
Bernasconi, E ;
Weber, R .
AIDS, 2001, 15 (14) :1793-1800
[9]   Does patient sex affect human immunodeficiency virus levels? [J].
Gandhi, M ;
Bacchetti, P ;
Miotti, P ;
Quinn, TC ;
Veronese, F ;
Greenblatt, RM .
CLINICAL INFECTIOUS DISEASES, 2002, 35 (03) :313-322
[10]   The effect of race/ethnicity on the outcome of highly active antiretroviral therapy for human immunodeficiency virus type 1-infected patients [J].
Jensen-Fangel, S ;
Pedersen, L ;
Pedersen, C ;
Larsen, CS ;
Tauris, P ;
Moller, A ;
Sorensen, HT ;
Obel, N .
CLINICAL INFECTIOUS DISEASES, 2002, 35 (12) :1541-1548