Microbial genes in the human genome: Lateral transfer or gene loss?

被引：202

作者：

Salzberg, SL ^{[1
]}

White, O ^{[1
]}

Peterson, J ^{[1
]}

Eisen, JA ^{[1
]}

机构：

[1] Inst Genome Res, Rockville, MD 20850 USA

来源：

SCIENCE | 2001年 / 292卷 / 5523期

关键词：

D O I：

10.1126/science.1061036

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human genome was analyzed for evidence that genes had been Laterally transferred into the genome from prokaryotic organisms. Protein sequence comparisons of the proteomes of human, fruit fly, nematode worm, yeast, mustard weed, eukaryotic parasites, and all completed prokaryote genomes were performed, and all genes shared between human and each of the other groups of organisms were collected. About 40 genes were found to be exclusively shared by humans and bacteria and are candidate examples of horizontal transfer from bacteria to vertebrates. Gene Loss combined with sample size effects and evolutionary rate variation provide an alternative, more biologically plausible explanation.

引用

页码：1903 / 1906

页数：4

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