Reflux, Barrett's oesophagus and adenocarcinoma: Burning questions

被引：215

作者：

Wild, CP ^{[1
]}

Hardie, LJ ^{[1
]}

机构：

[1] Univ Leeds, Sch Med, Mol Epidemiol Unit, Leeds LS2 9JT, W Yorkshire, England

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 09期

关键词：

D O I：

10.1038/nrc1166

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of oesophageal adenocarcinoma is increasing rapidly in Western populations. Gastro-oesophageal reflux disease is a strong risk factor for both this tumour and the precancerous lesion Barrett's oesophagus, but the underlying disease mechanisms remain unclear. Developing a better understanding of the aetiology and pathogenesis of Barrett's oesophagus, including the induction of DNA damage and genetic alterations, might provide opportunities for improved management of individuals with this disease. This could include a better rationale for screening and surveillance programmes, as well as targeted intervention strategies.

引用

页码：676 / U3

页数：10

共 117 条

[81]

Reid BJ, 2001, AM J GASTROENTEROL, V96, P2839

[82]

Riegman PHJ, 2001, CANCER RES, V61, P3164

[83] Familial aggregation of gastroesophageal reflux in patients with Barrett's esophagus and esophageal adenocarcinoma [J].

Romero, Y ;

Cameron, AJ ;

Locke, GR ;

Schaid, DJ ;

Slezak, JM ;

Branch, CD ;

Melton, LJ .

GASTROENTEROLOGY, 1997, 113 (05) :1449-1456

[84] Serum selenium levels in relation to markers of neoplastic progression among persons with Barrett's esophagus [J].

Rudolph, RE ;

Vaughan, TL ;

Kristal, AR ;

Blount, PL ;

Levine, DS ;

Galipeau, PC ;

Prevo, LJ ;

Sanchez, CA ;

Rabinovitch, PS ;

Reid, BJ .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2003, 95 (10) :750-757

[85] Mutations of p53 in Barrett's esophagus and Barrett's cancer: A prospective study of ninety-eight cases [J].

Schneider, PM ;

Casson, AG ;

Levin, B ;

Garewal, HS ;

Hoelscher, AH ;

Becker, K ;

Dittler, HJ ;

Cleary, KR ;

Troster, M ;

Siewert, JR ;

Roth, JA .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1996, 111 (02) :323-331

[86] Is there publication bias in the reporting of cancer risk in Barrett's esophagus? [J].

Shaheen, NJ ;

Crosby, MA ;

Bozymski, EM ;

Sandler, RS .

GASTROENTEROLOGY, 2000, 119 (02) :333-338

[87] Oxidative stress has a role in malignant transformation in Barrett's oesophagus [J].

Sihvo, EIT ;

Salminen, JT ;

Rantanen, TK ;

Rämö, OJ ;

Ahotupa, M ;

Färkkilä, M ;

Auvinen, MI ;

Salo, JA .

INTERNATIONAL JOURNAL OF CANCER, 2002, 102 (06) :551-555

[88] Review article: a conceptual approach to understanding the molecular mechanisms of cancer development in Barrett's oesophagus [J].

Souza, RF ;

Morales, CP ;

Spechler, SJ .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2001, 15 (08) :1087-1100

[89] Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease - Follow-up of a randomized controlled trial [J].

Spechler, SJ ;

Lee, E ;

Ahnen, D ;

Goyal, RK ;

Hirano, I ;

Ramirez, F ;

Raufman, JP ;

Sampliner, R ;

Schnell, T ;

Sontag, S ;

Vlahcevic, ZR ;

Young, R ;

Williford, W .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (18) :2331-2338

[90] Bile reflux in benign and malignant barrett’s esophagus: Effect of medical acid suppression and nissen fundoplication [J].

H. J. Stein ;

W. K. H. Kauer ;

H. Feussner ;

J. R. Siewert .

Journal of Gastrointestinal Surgery, 1998, 2 (4) :333-341

← 3 4 5 6 7 8 9 10 11 12 →