Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein

被引：14

作者：

Hamada, T

Ui-Tei, K

Imaki, J

Miyata, Y

机构：

[1] Nippon Med Sch, Dept Pharmacol, Bunkyo Ku, Tokyo 1138602, Japan

[2] Nippon Med Sch, Dept Anat, Bunkyo Ku, Tokyo 1138602, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 280卷 / 03期

关键词：

spinal cord-derived growth factor-B; SCDGF/PDGF-C/fallotein; CUB domain; mitogenic activity; PDGF/VEGF superfamily; EST;

D O I：

10.1006/bbrc.2000.4187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spinal cord-derived growth factor (SCDGF)/platelet-derived growth factor (PDGF)-C/fallotein has a unique two domain structure, as it contains two regions homologous to CUB and PDGF/vascular endothelial growth factor (VEGF) domains. In this study, we isolated a novel gene homologous to SCDGF/PDGF-C/fallotein, and named SCDGF-B. The culture supernatant of CHO-K1 cells stably transfected with SCDGF-B showed mitogenic activity as SCDGF/PDGF-C/fallotein did. Although SCDGF-B and SCDGF/PDGF-C/fallotein might be the members of the PDGF/VEGF superfamily of growth factors, they were categorized into a new subfamily in addition to PDGF and VEGF subfamilies. (C) 2001 Academic Press.

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收藏

页码：733 / 737

页数：5

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