STRUCTURAL BIOLOGY Proteins in dynamic equilibrium

被引:65
作者
Bernado, Pau [1 ]
Blackledge, Martin [2 ]
机构
[1] Inst Res Biomed, Barcelona 08028, Spain
[2] Univ Grenoble 1, CNRS, Inst Biol Struct Jean Pierre Ebel, CEA, F-38027 Grenoble, France
关键词
CRYSTAL-STRUCTURE; TYROSINE KINASE; SCATTERING; STATES; HCK;
D O I
10.1038/4681046a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
[No abstract available]
引用
收藏
页码:1046 / 1048
页数:3
相关论文
共 12 条
[1]   NMR spectroscopy brings invisible protein states into focus [J].
Baldwin, Andrew J. ;
Kay, Lewis E. .
NATURE CHEMICAL BIOLOGY, 2009, 5 (11) :808-814
[2]   Structural characterization of flexible proteins using small-angle X-ray scattering [J].
Bernado, Pau ;
Mylonas, Efstratios ;
Petoukhov, Maxim V. ;
Blackledge, Martin ;
Svergun, Dmitri I. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (17) :5656-5664
[3]   Conformational Space of Flexible Biological Macromolecules from Average Data [J].
Bertini, Ivano ;
Giachetti, Andrea ;
Luchinat, Claudio ;
Parigi, Giacomo ;
Petoukhov, Maxim V. ;
Pierattelli, Roberta ;
Ravera, Enrico ;
Svergun, Dmitri I. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (38) :13553-13558
[4]   The impact of structural genomics: Expectations and outcomes [J].
Chandonia, JM ;
Brenner, SE .
SCIENCE, 2006, 311 (5759) :347-351
[5]   The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation [J].
Cowan-Jacob, SW ;
Fendrich, G ;
Manley, PW ;
Jahnke, W ;
Fabbro, D ;
Liebetanz, J ;
Meyer, T .
STRUCTURE, 2005, 13 (06) :861-871
[6]   Dynamic personalities of proteins [J].
Henzler-Wildman, Katherine ;
Kern, Dorothee .
NATURE, 2007, 450 (7172) :964-972
[7]   Toward a Unified Representation of Protein Structural Dynamics in Solution [J].
Markwick, Phineus R. L. ;
Bouvignies, Guillaume ;
Salmon, Loic ;
McCammon, J. Andrew ;
Nilges, Michael ;
Blackledge, Martin .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (46) :16968-16975
[8]   Observing biological dynamics at atomic resolution using NMR [J].
Mittermaier, Anthony K. ;
Kay, Lewis E. .
TRENDS IN BIOCHEMICAL SCIENCES, 2009, 34 (12) :601-611
[9]   X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution [J].
Putnam, Christopher D. ;
Hammel, Michal ;
Hura, Greg L. ;
Tainer, John A. .
QUARTERLY REVIEWS OF BIOPHYSICS, 2007, 40 (03) :191-285
[10]   Crystal structure of the Src family tyrosine kinase Hck [J].
Sicheri, F ;
Moarefi, I ;
Kuriyan, J .
NATURE, 1997, 385 (6617) :602-609