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Molecular pathogenesis of Shigella spp.:: Controlling host cell signaling, invasion, and death by type III secretion
被引:421
作者:

Schroeder, Gunnar N.
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机构:
ETH, Inst Microbiol, CH-8093 Zurich, Switzerland ETH, Inst Microbiol, CH-8093 Zurich, Switzerland

Hilbi, Hubert
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机构:
ETH, Inst Microbiol, CH-8093 Zurich, Switzerland ETH, Inst Microbiol, CH-8093 Zurich, Switzerland
机构:
[1] ETH, Inst Microbiol, CH-8093 Zurich, Switzerland
关键词:
D O I:
10.1128/CMR.00032-07
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Shigella spp. are gram-negative pathogenic bacteria that evolved from harmless enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research performed over the last 25 years revealed that a type III secretion system (T3SS) encoded on a large plasmid is a key virulence factor of Shigella flexneri. The T3 S determines the interactions of S. flexneri with intestinal cells by consecutively translocating two sets of effector proteins into the target cells. Thus, S. flexneri controls invasion into EC, intra- and intercellular spread, macrophage cell death, as well as host inflammatory responses. Some of the translocated effector proteins show novel biochemical activities by which they intercept host cell signal transduction pathways. An understanding of the molecular mechanisms underlying Shigella pathogenesis will foster the development of a safe and efficient vaccine, which, in parallel with improved hygiene, should curb infections by this widespread pathogen.
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页码:134 / +
页数:24
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