Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines

被引：64

作者：

Daniels, R. Nathan ^{[1
]}

Kim, Kwangho ^{[1
]}

Lebois, Evan P. ^{[1
]}

Muchalski, Hubert ^{[1
]}

Hughes, Mary ^{[1
]}

Lindsley, Craig W. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr,Vanderbilt Inst Chem Biol, Vanderbilt Program Drug Discovery, Dept Chem & Pharmacol, Nashville, TN 37232 USA

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 02期

关键词：

D O I：

10.1016/j.tetlet.2007.11.054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

General, high-yielding MAOS protocols for the expedited synthesis of functionalized pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-b]pyrimidines, as well as their pyrazole precursors, are described amenable to an iterative analogue library synthesis strategy for lead optimization. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：305 / 310

页数：6

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