Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos

被引：379

作者：

Inoue, Azusa ^{[1
,2
]}

Zhang, Yi ^{[1
,2
]}

机构：

[1] Univ N Carolina, Howard Hughes Med Inst, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Biochem & Biophys, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

SCIENCE | 2011年 / 334卷 / 6053期

关键词：

ACTIVE DNA DEMETHYLATION; PATERNAL GENOME; MAMMALIAN DNA; TET PROTEINS; 5-METHYLCYTOSINE; 5-CARBOXYLCYTOSINE; CONVERSION;

D O I：

10.1126/science.1212483

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：194 / 194

页数：1

共 9 条

[1] Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain [J].

Guo, Junjie U. ;

Su, Yijing ;

Zhong, Chun ;

Ming, Guo-li ;

Song, Hongjun .

CELL, 2011, 145 (03) :423-434

[2] Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA [J].

He, Yu-Fei ;

Li, Bin-Zhong ;

Li, Zheng ;

Liu, Peng ;

Wang, Yang ;

Tang, Qingyu ;

Ding, Jianping ;

Jia, Yingying ;

Chen, Zhangcheng ;

Li, Lin ;

Sun, Yan ;

Li, Xiuxue ;

Dai, Qing ;

Song, Chun-Xiao ;

Zhang, Kangling ;

He, Chuan ;

Xu, Guo-Liang .

SCIENCE, 2011, 333 (6047) :1303-1307

[3] Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine [J].

Iqbal, Khursheed ;

Jin, Seung-Gi ;

Pfeifer, Gerd P. ;

Szabo, Piroska E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (09) :3642-3647

[4] Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine [J].

Ito, Shinsuke ;

Shen, Li ;

Dai, Qing ;

Wu, Susan C. ;

Collins, Leonard B. ;

Swenberg, James A. ;

He, Chuan ;

Zhang, Yi .

SCIENCE, 2011, 333 (6047) :1300-1303

[5] Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification [J].

Ito, Shinsuke ;

D'Alessio, Ana C. ;

Taranova, Olena V. ;

Hong, Kwonho ;

Sowers, Lawrence C. ;

Zhang, Yi .

NATURE, 2010, 466 (7310) :1129-U151

[6] Embryogenesis - Demethylation of the zygotic paternal genome [J].

Mayer, W ;

Niveleau, A ;

Walter, J ;

Fundele, R ;

Haaf, T .

NATURE, 2000, 403 (6769) :501-502

[7] Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1 [J].

Tahiliani, Mamta ;

Koh, Kian Peng ;

Shen, Yinghua ;

Pastor, William A. ;

Bandukwala, Hozefa ;

Brudno, Yevgeny ;

Agarwal, Suneet ;

Iyer, Lakshminarayan M. ;

Liu, David R. ;

Aravind, L. ;

Rao, Anjana .

SCIENCE, 2009, 324 (5929) :930-935

[8] 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming [J].

Wossidlo, Mark ;

Nakamura, Toshinobu ;

Lepikhov, Konstantin ;

Marques, C. Joana ;

Zakhartchenko, Valeri ;

Boiani, Michele ;

Arand, Julia ;

Nakano, Toru ;

Reik, Wolf ;

Walter, Joern .

NATURE COMMUNICATIONS, 2011, 2

[9] Active DNA demethylation: many roads lead to Rome [J].

Wu, Susan C. ;

Zhang, Yi .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2010, 11 (09) :607-620

← 1 →