Amberlite-IR 120 catalyzed three-component synthesis of α-amino phosphonates in one-pot

被引：107

作者：

Bhattacharya, Asish K. ^{[1
]}

Rana, Kalpeshkumar C.

机构：

[1] Natl Chem Lab, Combi Chem Bio Resource Ctr, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 16期

关键词：

alpha-amino phosphonates; aldehydes; amines; alkyl phosphite; ion-exchange resin; multi-component reaction;

D O I：

10.1016/j.tetlet.2008.02.102

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, and environmentally benign method for a three-component reaction of an amine, an aldehyde or a ketone, and diethyl phosphite catalyzed by Amberlite-IR 120 resin has been developed to afford alpha-amino phosphonates in high yields and short reaction times under solvent-free reaction conditions. The major advantages of the present method are good yields, inexpensive, ecofriendly and reusable catalyst, mild and solvent-free reaction conditions and tolerance towards various functionalities present in the substrates. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2598 / 2601

页数：4

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