Rhodopsin: A structural primer for G-protein coupled receptors

被引：38

作者：

Stenkamp, RE

Teller, DC

Palczewski, K

机构：

[1] Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA

[2] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

[3] Univ Washington, Biomol Struct Ctr, Seattle, WA 98195 USA

[4] Univ Washington, Dept Ophthalmol, Seattle, WA 98195 USA

[5] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

[6] Univ Washington, Dept Chem, Seattle, WA 98195 USA

来源：

ARCHIV DER PHARMAZIE | 2005年 / 338卷 / 5-6期

关键词：

G protein-coupled receptors; membrane proteins; photoreceptor cells; rhodopsin;

D O I：

10.1002/ardp.200400995

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An overview of the rhodopsin crystal structure provides a structural basis for understanding the structures and functions of other G-protein coupled receptors (GPCRs). All of the structural details observed to date for rhodopsin will not necessarily carry over to other GPCRs, but major features such as the arrangement of the seven transmembrane helices, the retinal/ligand binding site, the D(E)RY and NPXXY sequence and structural motifs, and the bent helices are likely characteristics of the GPCRs most closely related to rhodopsin. A general view of these structural features is presented here.

引用

收藏

页码：209 / 216

页数：8

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