Functional characteristics of human peripheral blood α/βTCR+, CD4- and CD8- double-negative (DN) T cells

被引：8

作者：

Niehues, T

Eichelbauer, D

Schneider, EM

机构：

[1] Univ Dusseldorf, Zentrum Kinderheilkunde, Dept Pediat, D-40001 Dusseldorf, Germany

[2] Univ Dusseldorf, Dept Transfus Med, D-40001 Dusseldorf, Germany

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1999年 / 43卷 / 02期

关键词：

human; blood; T lymphocytes; cellular activation;

D O I：

10.1111/j.1348-0421.1999.tb02386.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The function of human peripheral blood alpha/beta TCR positive, CD4- and CD8- double-negative T lymphocytes (DN cells) in vivo is not completely understood. The response of; immunomagnetically isolated DN cells to PHA and anti-CD3 was compared to the response of single-positive (SP) CD4 and CD8 subsets. Proliferation of DN cells in response to PHA was largely independent of APC. This suggests activation requirements for DN cells that are different from SIP cells, Upon activation, HLA-DR was found to be upregulated early on DN cells, and IL-4 and IL-10 were detected in the supernatants of DN cells. These observations in vitro could correspond with an immunoregulatory role of human DN cells in vivo.

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收藏

页码：153 / 159

页数：7

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