Structural analysis of chloroquine resistance reversal by imipramine analogs

被引：22

作者：

Bhattacharjee, AK

Kyle, DE

Vennerstrom, JL

机构：

[1] Univ Nebraska, Med Ctr, Coll Pharm, Nebraska Med Ctr 986025, Omaha, NE 68198 USA

[2] Walter Reed Army Inst Res, Dept Med Chem, Washington, DC 20307 USA

[3] Walter Reed Army Inst Res, Dept Parasitol, Washington, DC 20307 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 09期

关键词：

D O I：

10.1128/AAC.45.9.2655-2657.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic nitrogen atom was unnecessary for resistance reversal, the direction of the dipole moment vector was critical.

引用

页码：2655 / 2657

页数：3

共 15 条

[1] CHLOROQUINE-POTENTIATING ACTION OF ANTIHISTAMINICS IN PLASMODIUM-FALCIPARUM INVITRO
BASCO, LK
RINGWALD, P
LEBRAS, J
[J]. ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1991, 85 (02): : 223 - 228
[2] REVERSAL OF CHLOROQUINE RESISTANCE WITH DESIPRAMINE IN ISOLATES OF PLASMODIUM-FALCIPARUM FROM CENTRAL AND WEST-AFRICA
BASCO, LK
LEBRAS, J
[J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1990, 84 (04) : 479 - 481
[3] BATRA S, 1997, ADV DRUG RES, V30, P202
[4] REVERSAL OF CHLOROQUINE RESISTANCE IN MALARIA PARASITE PLASMODIUM-FALCIPARUM BY DESIPRAMINE
BITONTI, AJ
SJOERDSMA, A
MCCANN, PP
KYLE, DE
ODUOLA, AMJ
ROSSAN, RN
MILHOUS, WK
DAVIDSON, DE
[J]. SCIENCE, 1988, 242 (4883) : 1301 - 1303
[5] REVERSAL OF CHLOROQUINE RESISTANCE OF WILD ISOLATES OF PLASMODIUM-FALCIPARUM BY DESIPRAMINE
CAROSI, G
CALIGARIS, S
FADAT, G
CASTELLI, F
MATTEELLI, A
KOUKABEMBA, D
ROSCIGNO, G
[J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (06) : 723 - 724
[6] DIXON RW, 1993, ISRAEL J CHEM, V33, P427
[7] ANTIMALARIAL PROPERTIES OF IMIPRAMINE AND AMITRIPTYLINE
DUTTA, P
PINTO, J
RIVLIN, R
[J]. JOURNAL OF PROTOZOOLOGY, 1990, 37 (01): : 54 - 58
[8] Antimalarial effect in vitro and lack of modulating effect of desipramine and imipramine
Menezes, CMS
Kirchgatter, K
Di Santi, SMF
Savalli, C
Monteiro, FG
Paula, GA
Ferreira, EI
[J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1997, 91 (06) : 697 - 700
[9] COMPARATIVE-ANALYSIS OF THE ELECTROSTATIC POTENTIALS OF DIBENZOFURAN AND SOME DIBENZO-PARA-DIOXINS
MURRAY, JS
ZILLES, BA
JAYASURIYA, K
POLITZER, P
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (05) : 915 - 918
[10] PETERS W, 1989, LANCET, V2, P334, DOI 10.1016/S0140-6736(89)90522-9

← 1 2 →