Resistance to cisatracurium in a patient with MELAS syndrome

被引:13
作者
Aouad, MT [1 ]
Gerges, FJ [1 ]
Baraka, AS [1 ]
机构
[1] Amer Univ Beirut, Med Ctr, Dept Anaesthesiol, Beirut 0236, Lebanon
关键词
mitochondrial myopathy; nondepolarizing muscle relaxants; up-regulation;
D O I
10.1111/j.1460-9592.2005.01583.x
中图分类号
R614 [麻醉学];
学科分类号
100217 [麻醉学];
摘要
There are conflicting reports on the response of mitochondrial myopathy patients to the neuromuscular blocking drugs, showing either normal response or marked sensitivity. We present a patient with MELAS syndrome who underwent Nissen fundoplication and gastrojejunostomy. Marked resistance to the nondepolarizing muscle relaxant, cisatracurium was observed. The anesthesia management, as well as the various causes of resistance to cisatracurium in this patient are discussed.
引用
收藏
页码:1124 / 1127
页数:4
相关论文
共 24 条
[1]
BARAKA A, 1974, ANESTH ANALG, V53, P594
[2]
Baraka Anis, 1996, Middle East Journal of Anesthesiology, V13, P561
[3]
ANESTHESIA FOR PATIENTS WITH MITOCHONDRIAL MYOPATHY [J].
BURNS, AM ;
SHELLY, MP .
ANAESTHESIA, 1989, 44 (12) :975-977
[4]
KEARNS-SAYER SYNDROME AND "PANCURONIUM-SUCCINYLCHOLINE-INDUCED NEUROMUSCULAR BLOCKADE [J].
DAMBRA, MN ;
DEDRICK, D ;
SAVARESE, JJ .
ANESTHESIOLOGY, 1979, 51 (04) :343-345
[5]
Accelerated recovery and disposition from rocuronium in an end-stage renal failure patient on chronic anticonvulsant therapy with sodium valproate and primidone [J].
Driessen, JJ ;
Robertson, EN ;
Booij, LHDJ ;
Vree, TB .
BRITISH JOURNAL OF ANAESTHESIA, 1998, 80 (03) :386-388
[6]
Increased sensitivity to rocuronium and atracurium in mitochondrial myopathy [J].
Finsterer, J ;
Stratil, U ;
Bittner, R ;
Sporn, P .
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 1998, 45 (08) :781-784
[7]
Cardiac arrest after succinylcholine - Mortality greater with Rhabdomyolysis than receptor upregulation [J].
Gronert, GA .
ANESTHESIOLOGY, 2001, 94 (03) :523-529
[8]
RESISTANCE TO NONDEPOLARIZING NEUROMUSCULAR BLOCKING-AGENTS [J].
HUNTER, JM .
BRITISH JOURNAL OF ANAESTHESIA, 1991, 67 (05) :511-514
[9]
Cisatracurium-induced neuromuscular blockade in anticonvulsant treated neurosurgical patients [J].
Koenig, HM ;
Edwards, TL .
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 2000, 12 (04) :314-318
[10]
THE COEXISTENCE OF EMBRYONIC AND ADULT ACETYLCHOLINE-RECEPTORS IN SARCOLEMMA OF MDX DYSTROPHIC MOUSE MUSCLE - AN EFFECT OF REGENERATION OR MUSCULAR-DYSTROPHY [J].
KOLTGEN, D ;
FRANKE, C .
NEUROSCIENCE LETTERS, 1994, 173 (1-2) :79-82