THE COEXISTENCE OF EMBRYONIC AND ADULT ACETYLCHOLINE-RECEPTORS IN SARCOLEMMA OF MDX DYSTROPHIC MOUSE MUSCLE - AN EFFECT OF REGENERATION OR MUSCULAR-DYSTROPHY

被引：18

作者：

KOLTGEN, D ^{[1
]}

FRANKE, C ^{[1
]}

机构：

[1] TECH UNIV MUNICH,NEUROL KLIN,D-81675 MUNICH,GERMANY

来源：

NEUROSCIENCE LETTERS | 1994年 / 173卷 / 1-2期

关键词：

MUSCULAR DYSTROPHY; BUPIVACAINE; REGENERATION; NICOTINIC ACETYLCHOLINE RECEPTOR; MDX MOUSE;

D O I：

10.1016/0304-3940(94)90154-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In the sarcolemma of innervated dystrophic mdx mouse muscle we found the embryonic and the adult nicotinic acetylcholine receptor, where normally after innervation only the adult type would be expected, as can be shown with comparative data from patch-damp experiments from wildtype and wildtype-denervated muscle. As a control to the dystrophic muscle we investigated wildtype bupivacain-treated regenerating muscle and found both receptor types there, too. Therefore we conclude that the expression of the embryonic nicotinic acetylcholine receptor in the dystrophic muscle is not a characteristic of dystrophy but a consequence of muscle regeneration.

引用

页码：79 / 82

页数：4

共 17 条

[1]

ARAVACA Y, 1984, MOL PHARMACOL, V26, P304

[2]

ACTIVATION OF THE PRIMARY KINETIC MODES OF LARGE-CONDUCTANCE AND SMALL-CONDUCTANCE CHOLINERGIC ION CHANNELS IN XENOPUS MYOCYTES [J].