Pathways to understanding the genomic aetiology of osteoarthritis

被引：34

作者：

Uhalte, Elena Cibrian ^{[1
]}

Wilkinson, Jeremy Mark ^{[2
]}

Southam, Lorraine ^{[3
,4
]}

Zeggini, Eleftheria ^{[4
]}

机构：

[1] Wellcome Trust Sanger Inst, Human Genet & Cellular Genet, Hinxton CB10 1SA, England

[2] Univ Sheffield, Dept Oncol & Metab, Sheffield S10 2RX, S Yorkshire, England

[3] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[4] Wellcome Trust Sanger Inst, Human Genet, Hinxton CB10 1SA, England

来源：

HUMAN MOLECULAR GENETICS | 2017年 / 26卷 / R2期

基金：

英国惠康基金;

关键词：

OLIGOMERIC MATRIX PROTEIN; WIDE DNA METHYLATION; KNEE OSTEOARTHRITIS; GENE-EXPRESSION; ARTICULAR CHONDROCYTES; PATIENT SATISFACTION; SUSCEPTIBILITY LOCI; NATIONAL-HEALTH; CANDIDATE GENES; SYNOVIAL-FLUID;

D O I：

10.1093/hmg/ddx302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Osteoarthritis is a common, complex disease with no curative therapy. In this review, we summarize current knowledge on disease aetiopathogenesis and outline genetics and genomics approaches that are helping catalyse a much-needed improved understanding of the biological underpinning of disease development and progression.

引用

页码：R193 / R201

页数：9

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