Incentive motivation is associated with striatal dopamine asymmetry

被引：76

作者：

Tomer, Rachel ^{[1
]}

Goldstein, Rita Z. ^{[2
]}

Wang, Gene-Jack ^{[2
]}

Wong, Christopher ^{[2
]}

Volkow, Nora D. ^{[3
]}

机构：

[1] Univ Haifa, Dept Psychol, IL-31905 Haifa, Israel

[2] Univ Haifa, Brain & Behav Ctr, IL-31905 Haifa, Israel

[3] Natl Inst Drug Abuse, Bethesda, MD USA

来源：

BIOLOGICAL PSYCHOLOGY | 2008年 / 77卷 / 01期

关键词：

dopamine; asymmetry; motivation; striatum;

D O I：

10.1016/j.biopsycho.2007.08.001

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Dopamine plays an important role in modulating incentive motivation, expressed behaviorally as approach behavior. EEG studies report association between approach behavior and asymmetric pattern of activation in anterior cortical regions (as measured by the inverse of EEG alpha power). Therefore. individual differences in incentive motivation may reflect asymmetries in dopaminergic systems. We examined this hypothesis by studying the relationship between self-reported degree of incentive motivation, and asymmetry of D2 receptor availability in healthy volunteers. Nineteen healthy participants were studied with positron emission tomography (PET) and [11C]raclopride to assess the availability of dopamine D2 receptors in left and right striatum. Incentive motivation was assessed by the Achievement scale of the Multidimensional Personality Questionnaire. The Achievement score was negatively correlated with the Asymmetry Index ([R - L]/[R + L]) of D2 receptor availability (r = -.721, p = .001), suggesting that greater positive incentive motivation is associated with higher receptor availability in the left relative to the right hemisphere. (C) 2007 Elsevier B.V. All fights reserved.

引用

页码：98 / 101

页数：4

共 22 条

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