Hospital resources consumed for surgical morbidity:: effects of preoperative arginine and ω-3 fatty acid supplementation on costs

Objective: Costs related to postoperative complications continue to be a major burden on anyhealth care system. The aim of the present study was to calculate hospital costs for postoperative complications and to evaluate whether preoperative supplementation with omega-3 fatty acids and arginine (specialized diet) might lead to cost savings in patient care. Methods: Blind analysis of costs performed on data gathered from a randomized clinical trial carried out on 305 patients with gastrointestinal cancer showed that an oral preoperative specialized diet decreased postoperative morbidity compared with conventional treatment (no supplementation). Estimates of complication costs were based on resources used for treatment and on additional length of hospital stay. Cost-comparison and cost-effectiveness analyses were then carried out. Results: The mean cost of postoperative complications was EURO4492. The greatest amount of resources was consumed by 19 anastomotic leaks (EURO159803), 18 abdominal abscesses (EURO12 921), and 18 pancreatic fistulae (EURO106 516). The mean costs per complication were EURO6178 in the conventional group and EURO4639 in the preoperative group (P = 0.05). The mean total costs of patients with complications were EURO10 494 in the conventional group and EURO8793 in the preoperative group. The mean cost per randomized patient was EURO3122 in the conventional group versus EURO1872 in the preoperative group (P = 0.04). Effectiveness values were 50.0% in the conventional group and 62.8% in the preoperative group (P = 0.03). Total costs consumed 93% of the diagnosis-related group reimbursement rate in the conventional group and 78% in the preoperative group. Conclusions: The costs of postoperative morbidity consumed a large amount of the diagnosis- related group reimbursement rate. Preoperative supplementation with the specialized diet appears to be a cost-effective treatment. (c) 2005 Elsevier Inc. All rights reserved.