HIV - Setting death in motion

被引：17

作者：

Ameisen, JC ^{[1
]}

机构：

[1] Univ Paris 07, Hop Bichat, INSERM, CJF 9707, F-75788 Paris 18, France

来源：

NATURE | 1998年 / 395卷 / 6698期

关键词：

D O I：

10.1038/25851

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It's well known that HIV infects cells bearing the CD4 receptor, but one long-standing puzzle has been how the virus induces the death of other cells — nerve cells and T cells that bear the CD8 receptor, for example. It turns out that HIV may do this by subverting newly discovered death signals from the very chemokines that normally protect the body from infection.

引用

页码：117 / +

页数：2

共 13 条

[1] CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis
Algeciras, A
Dockrell, DH
Lynch, DH
Paya, C
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (05) : 711 - 720
[2] THE RELEVANCE OF APOPTOSIS TO AIDS PATHOGENESIS
AMEISEN, JC
ESTAQUIER, J
IDZIOREK, T
DEBELS, F
[J]. TRENDS IN CELL BIOLOGY, 1995, 5 (01) : 27 - 32
[3] Macrophage-dependent apoptosis of CD4(+) T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor
Badley, AD
Dockrell, D
Simpson, M
Schut, R
Lynch, DH
Leibson, P
Paya, CV
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (01) : 55 - 64
[4] HIV-specific T cell cytotoxicity mediated by RANTES via the chemokine receptor CCR3
Hadida, F
Vieillard, V
Autran, B
Clark-Lewis, I
Baggiolini, M
Debré, P
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (03) : 609 - 614
[5] Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4
Herbein, G
Mahlknecht, U
Batliwalla, F
Gregersen, P
Pappas, T
Butler, J
O'Brien, WA
Verdin, E
[J]. NATURE, 1998, 395 (6698) : 189 - 194
[6] Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
Hesselgesser, J
Taub, D
Baskar, P
Greenberg, M
Hoxie, J
Kolson, DL
Horuk, R
[J]. CURRENT BIOLOGY, 1998, 8 (10) : 595 - 598
[7] A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus
Kledal, TN
Rosenkilde, MM
Coulin, F
Simmons, G
Johnsen, AH
Alouani, S
Power, CA
Luttichau, HR
Gerstoft, J
Clapham, PR
ClarkLewis, I
Wells, TNC
Schwartz, TW
[J]. SCIENCE, 1997, 277 (5332) : 1656 - 1659
[8] Vigorous HIV-1-specific CD4(+) T cell responses associated with control of viremia
Rosenberg, ES
Billingsley, JM
Caliendo, AM
Boswell, SL
Sax, PE
Kalams, SA
Walker, BD
[J]. SCIENCE, 1997, 278 (5342) : 1447 - 1450
[9] Apoptosis - Phagocytic docking without shocking
Savill, J
[J]. NATURE, 1998, 392 (6675) : 442 - 443
[10] Chemokines and T lymphocytes: More than an attraction
Ward, SG
Bacon, K
Westwick, J
[J]. IMMUNITY, 1998, 9 (01) : 1 - 11

← 1 2 →