Synthesis of cationic β-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1

被引：42

作者：

Silva, EMP

Giuntini, F

Faustino, MAF

Tomé, JPC

Neves, MGPMS

Tomé, AC

Silva, AMS

Santana-Marques, MG

Ferrer-Correia, AJ

Cavaleiro, JAS ^{[1
]}

Caeiro, MF

Duarte, RR

Tavares, SAP

Pegado, IN

d'Almeida, B

De Matos, APA

Valdeira, ML

机构：

[1] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal

[2] Univ Lisbon, Fac Sci, Dept Plant Biol, P-1749016 Lisbon, Portugal

[3] Univ Lisbon, Fac Pharm, Ctr Pathogeneses Mol, P-1649019 Lisbon, Portugal

[4] Univ Lisbon, Sch Dent Med, Biomat Dept, P-1649003 Lisbon, Portugal

[5] Curry Cabral Hosp, Dept Pathol Anat, P-1069166 Lisbon, Portugal

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 14期

关键词：

porphyrins; aldol condensation; HSV-1; herpesviruses;

D O I：

10.1016/j.bmcl.2005.05.044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An easy route to cationic beta-vinyl substituted meso-tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3333 / 3337

页数：5

共 36 条

[11]

Burrell AK, 1998, SYNLETT, P1297

[12] Famciclovir: Review of clinical efficacy and safety [J].