Membrane-bound transcription factors: regulated release by RIP or RUP

被引：130

作者：

Hoppe, T ^{[1
]}

Rape, M ^{[1
]}

Jentsch, S ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0955-0674(00)00218-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulated nuclear transport of transcription factors from cytoplasmic pools is a major route by which eukaryotes control gene expression. Exquisite examples are transcription factors that are kept in a dormant state in the cytosol by membrane anchors; such proteins are released from membranes by proteolytic cleavage, which enables these transcription factors to enter the nucleus. Cleavage can be mediated either by regulated intramembrane proteolysis (RIP) catalysed by specific membrane-bound proteases or by regulated ubiquitin/proteasome-dependent processing (RUP). In both cases processing can be controlled by cues that originate at or in the vicinity of the membrane.

引用

页码：344 / 348

页数：5

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