Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen

被引：112

作者：

Briviba, K ^{[1
]}

Roussyn, I ^{[1
]}

Sharov, VS ^{[1
]}

Sies, H ^{[1
]}

机构：

[1] UNIV DUSSELDORF,INST PHYSIOL CHEM 1,D-40001 DUSSELDORF,GERMANY

来源：

BIOCHEMICAL JOURNAL | 1996年 / 319卷

关键词：

D O I：

10.1042/bj3190013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of the selenium-containing compounds selenomethionine, selenocystine and ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one] on the oxidation of dihydrorhodamine 123 caused by peroxynitrite and on the nitration of 4-hydroxy-phenylacetate by peroxynitrite was studied in comparison with their sulphur analogues methionine, cystine and ebsulfur [2-phenyl-1,2-benzisothiazol-3(2H)-one]. The selenocompounds protected dihydrorhodamine 123 from oxidation and 4-hydroxyphenylacetate from nitration more effectively than their sulphur analogues. Sodium selenite exhibited no effect. These observations are corollaries to the recent finding [Roussyn, Briviba, Masumoto and Sies (1996) Arch. Biochem. Biophys. 330, 216-218] that selenium-containing compounds are efficient in protecting against peroxynitrite-induced DNA single-strand breaks.

引用

页码：13 / 15

页数：3