Differential effect of clopidogrel and aspirin on the release of BDNF from platelets

被引：28

作者：

Stoll, Paul ^{[1
]}

Plessow, Annett ^{[1
]}

Bratke, Kai ^{[1
]}

Virchow, J. Christian ^{[1
]}

Lommatzsch, Marek ^{[1
]}

机构：

[1] Univ Rostock, Dept Pneumol, D-18057 Rostock, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 238卷 / 1-2期

关键词：

Aspirin; Brain-derived neurotrophic factor; Clopidogrel; Platelet; Stroke; NEUROTROPHIC FACTOR; RECOVERY; STROKE;

D O I：

10.1016/j.jneuroim.2011.06.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Anti-platelet treatment is a key therapeutic intervention in patients with cerebrovascular diseases. However, there is no information on its impact on the release of Brain-derived neurotrophic factor (BDNF), which is stored in large amounts in human platelets and essential for neuronal protection and repair. Here, we show that a single oral dose of clopidogrel, but not aspirin, significantly reduced the release of BDNF from platelets in healthy volunteers. These data point, for the first time, to possible differential effects of anti-platelet regimens on neuronal function in patients with cerebrovascular disorders. (C) 2011 Elsevier B.V. All rights reserved.

引用

收藏

页码：104 / 106

页数：3

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