Copy Number Imbalances between Screen- and Symptom-Detected Breast Cancers and Impact on Disease-Free Survival

被引:13
作者
Brewster, A. M. [1 ]
Thompson, P. [7 ]
Sahin, A. A. [2 ]
Do, K. [3 ]
Edgerton, M. [2 ]
Murray, J. L. [4 ]
Tsavachidis, S. [5 ]
Zhou, R. [5 ]
Liu, Y. [5 ]
Zhang, L. [3 ]
Mills, G. [6 ]
Bondy, M. [5 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, Houston, TX 77230 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77230 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77230 USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77230 USA
[5] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77230 USA
[6] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77230 USA
[7] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA
关键词
COMPARATIVE GENOMIC HYBRIDIZATION; CHROMOSOMAL IMBALANCES; GENETIC ALTERATIONS; ADIPONECTIN; INTERVAL; PATTERNS; TUMORS; CELLS; RISK; AGGRESSIVENESS;
D O I
10.1158/1940-6207.CAPR-10-0361
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Screening mammography results in the increased detection of indolent tumors. We hypothesized that screen-and symptom-detected tumors would show genotypic differences as copy number imbalances (CNI) that, in part, explain differences in the clinical behavior between screen-and symptom-detected breast tumors. We evaluated 850 women aged 40 and above diagnosed with stage I and II breast cancer at the University of Texas MD Anderson Cancer Center between 1985 and 2000 with information available on method of tumor detection (screen vs. symptoms). CNIs in screen-and symptom-detected tumors were identified using high-density molecular inversion probe arrays. Cox proportional modeling was used to estimate the effect of method of tumor detection on disease-free survival after adjusting for age, stage, and the CNIs. The majority of tumors were symptom detected (n = 603) compared with screen detected (n 247). Copy number gains in chromosomes 2p, 3q, 8q, 11p, and 20q were associated with method of breast cancer detection (P < 0.00001). We estimated that 32% and 63% of the survival advantage of screen detection was accounted for by age, stage, nuclear grade, and Ki67 in women aged 50 to 70 and aged 40 to 87, respectively. In each age category, an additional 20% of the survival advantage was accounted for by CNIs associated with method of detection. Specific CNIs differ between screen- and symptom-detected tumors and explain part of the survival advantage associated with screen-detected tumors. Measurement of tumor genotype has the potential to improve discrimination between indolent and aggressive screen-detected tumors and aids patient and physician decision making about use of surgical and adjuvant treatments. Cancer Prev Res; 4(10); 1609-16. (C)2011 AACR.
引用
收藏
页码:1609 / 1616
页数:8
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