Enhanced activation of B cells in a granulocyte colony-stimulating factor-mobilized peripheral blood stem cell graft

被引：24

作者：

Tayebi, H

Lapierre, V

Saas, P

Lienard, A

Sutton, L

Milpied, N

Attal, M

Cahn, JY

Kuentz, M

Blaise, D

Hervé, P

Tiberghien, P

Robinet, E

机构：

[1] Etab Francais Sang Bourgogne Franche Comte, Lab Therapeut Immunomol, INSERM, UPRES EA 2284, F-25020 Besancon, France

[2] Inst Gustave Roussy, Unite Med Transfus & Hemovigilance, Villejuif, France

[3] Inst Gustave Roussy, Com Secur Transfus & Hemovigilance, Villejuif, France

[4] Hop La Pitie Salpetriere, Serv Hematol Clin, Paris, France

[5] Hop Hotel Dieu, Serv Hematol, Nantes, France

[6] Hop Purpan, Serv Hematol, Toulouse, France

[7] Hop Jean Minjoz, Serv Hematol, F-25030 Besancon, France

[8] Hop Henri Mondor, Serv Hematol, F-94010 Creteil, France

[9] Inst J Paoli I Calmettes, Unite Transplantat Medullaire, F-13009 Marseille, France

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 114卷 / 03期

关键词：

B cells; activation; peripheral blood stem cells; CD45RO; G-CSF;

D O I：

10.1046/j.1365-2141.2001.02965.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a randomized study that compared human leucocyte antigen-identical allogeneic granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cell (PBSC) versus bone marrow (BM) transplantation, the expression of activation markers, CD23, CD25 and CD45RO by B cells, was compared in blood before and after G-CSF mobilization and in PBSC versus BM grafts. The fractions of CD23(+) and CD25(+) B cells were higher in PBSC than in BM grafts. Moreover, we observed a G-CSF-induced increase in B-cell fractions in blood as well as in PBSC grafts when compared with BM grafts. Such an enhanced B-cell activation could contribute to the accelerated kinetics of immuno-haematological reconstitution, the occurrence of acute haemolysis in the ABO minor incompatibility setting, as well as the increased incidence of chronic graft-versus-host disease observed after PBSC transplantation.

引用

页码：698 / 700

页数：3

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