Assessment of homocysteine as a cardiovascular risk factor in clinical practice

被引：46

作者：

Clarke, R ^{[1
]}

Stansbie, D

机构：

[1] Radcliffe Infirm, Nuffield Dept Clin Med, Clin Trial Serv Unit, Oxford OX2 6HE, England

[2] Radcliffe Infirm, Nuffield Dept Clin Med, Epidemiol Studies Unit, Oxford OX2 6HE, England

[3] Bristol Royal Infirm & Gen Hosp, Dept Chem Pathol, Bristol BS2 8HW, Avon, England

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 2001年 / 38卷

关键词：

D O I：

10.1258/0004563011901046

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Elevated plasma total homocysteine concentrations are a marker of vitamin deficiency and a risk factor for cardiovascular disease. It is possible that vitamin supplementation with folic acid and other B vitamins, which lower plasma homocysteine concentrations, may reduce the risk or cardiovascular disease. Large-scale clinical trials are currently underway to assess the homocysteine hypothesis of cardiovascular disease. Pending the outcome of such trials, measurement of plasma homocysteine concentrations in people at high risk of cardiovascular disease may help to identify patients who Could benefit from more intensive treatment of classical cardiovascular risk factors. The introduction of immunoassays for homocysteine determination has made assessment of homocysteine status accessible to most routine hospital laboratories, and this review summarizes the evidence on why and how to assess homocysteine as a risk factor for cardiovascular disease in clinical practice.

引用

页码：624 / 632

页数：9

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