Pinning NF-κB to the nucleus

被引：10

作者：

Ben-Neriah, Y ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Immunol, IL-91120 Jerusalem, Israel

来源：

MOLECULAR CELL | 2003年 / 12卷 / 06期

关键词：

D O I：

10.1016/S1097-2765(03)00493-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The peptidyl-prolyl isomerase Pin1 binds and stabilizes several phosphorylated transcription and mitosis regulators via its WW interacting domain. It is overexpressed ;in breast tumors and, as Ryo et al. (2003b) discuss in this issue of Molecular Cell, could account for their constitutive nuclear NF-kappaB expression. The proposed mechanism involves protection of Pin1-bound p65 against SOCS-1-mediated ubiquitination.

引用

页码：1344 / 1345

页数：2

共 11 条

[1] NF-κB activation in cancer:: a challenge for ubiquitination- and proteasome-based therapeutic approach [J].

Amit, S ;

Ben-Neriah, Y .

SEMINARS IN CANCER BIOLOGY, 2003, 13 (01) :15-28

[2] EMBRYONIC LETHALITY AND LIVER DEGENERATION IN MICE LACKING THE RELA COMPONENT OF NF-KAPPA-B [J].

BEG, AA ;

SHA, WC ;

BRONSON, RT ;

GHOSH, S ;

BALTIMORE, D .

NATURE, 1995, 376 (6536) :167-170

[3] Mechanisms of ubiquitin-mediated, limited processing of the NF-κB1 precursor protein p105 [J].

Ciechanover, A ;

Gonen, H ;

Bercovich, B ;

Cohen, S ;

Fajerman, I ;

Israël, A ;

Mercurio, F ;

Kahana, C ;

Schwartz, AL ;

Iwai, K ;

Orian, A .

BIOCHIMIE, 2001, 83 (3-4) :341-349

[4] Selective activation of NF-κB subunits in human breast cancer:: potential roles for NF-κB2/p52 and for Bcl-3 [J].

Cogswell, PC ;

Guttridge, DC ;

Funkhouser, WK ;

Baldwin, AS .

ONCOGENE, 2000, 19 (09) :1123-1131

[5] Constitutive nuclear factor κB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells [J].

Davis, RE ;

Brown, KD ;

Siebenlist, U ;

Staudt, LM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (12) :1861-1874

[6] Missing pieces in the NF-κB puzzle [J].

Ghosh, S ;

Karin, M .

CELL, 2002, 109 :S81-S96

[7] SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice [J].

Lindeman, GJ ;

Wittlin, S ;

Lada, H ;

Naylor, MJ ;

Santamaria, M ;

Zhang, JG ;

Starr, R ;

Hilton, DJ ;

Alexander, WS ;

Ormandy, CJ ;

Visvader, J .

GENES & DEVELOPMENT, 2001, 15 (13) :1631-1636

[8] How the ubiquitin-proteasome system controls transcription [J].

Muratani, M ;

Tansey, WR .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (03) :192-201

[9] NF-κB as a therapeutic target in cancer [J].

Orlowski, RZ ;

Baldwin, AS .

TRENDS IN MOLECULAR MEDICINE, 2002, 8 (08) :385-389

[10] Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer [J].

Ryo, A ;

Liou, YC ;

Lu, KP ;

Wulf, G .

JOURNAL OF CELL SCIENCE, 2003, 116 (05) :773-783

← 1 2 →