New pyrophosphate analogues:: a facile access to N-(O-alkylsulfamoyl)phosphoramidic acids via a simple and quantitative reaction, of N-(O-alkylsulfamoyl)trimethylphospha-λ5-azene with bromotrimethylsilane and water

A new strategy to prepare pyrophosphate analogues through selective and quantitative cleavage of N-(O-alkylsulfamoyl)tri-alkylphospha-gimel5 -azene esters (R-O-SO2-N=P(OR')(3)) has been developed. Using pure bromotrimethylsilane, N-(O-alkyl-sulfamoyl)tris-trimethylsilylphospha-gimel(5)-azenes (R-O-SO2-N=P(OSiMe3)(3)) have been easily obtained as intermediates. N-(O-Alkyl-sulfamoyl)phosphoramidic acids (R-O-SO2-NH-P(O)(OH)(2)) have been formed quantitatively by hydrolysis of the silylated intermediates. (C) 2004 Elsevier Ltd. All rights reserved.