Midterm angiographic outcome of single-vessel intracoronary stent placement in diabetic versus nondiabetic patients: A matched comparative study

Background It remains controversial whether diabetes is associated with an increased risk of restenosis after intracoronary stenting. Methods and Results We selected 42 diabetic patients and an equal number of nondiabetic patients with followup angiographic restudy after single-vessel stenting, matched for 4 important stent-related and angiographic variables (stent design, reference vessel size and expanded stent diameter, coronary vessel treated, and poststent residual diameter stenosis). The 2 patient groups did not differ in their baseline lesion severity and acute luminal gain. At 5-month angiographic assessment, the observed in-stent restenosis rate was significantly higher in diabetic than nondiabetic patients (40.5% vs 16.7%, P = 0.0157). It was highest in diabetic patients who received small stents <3.0 mm in diameter and intermediate in diabetic patients who received larger stent sizes (55% vs 27%, P = 0.0675). The frequency of restenosis in nondiabetic patients, however, was low; it was 18% and 15% in those who received small stents and larger stents, respectively (P = 0.7823). Conclusions Our data suggest that diabetes predisposes to on increased risk of in-stent restenosis, particularly in small vessels.