Intramolecular carbolithiation reactions for the preparation of 3-alkenylpyrrolidines

被引：30

作者：

Coldham, I ^{[1
]}

Price, KN ^{[1
]}

Rathmell, RE ^{[1
]}

机构：

[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 12期

关键词：

D O I：

10.1039/b303670g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tin-lithium exchange allows the formation of alpha-amino-organolithium species that undergo anionic cyclization onto allylic ethers to give 3-alkenylpyrrolidines. The methodology has been applied to the synthesis of an advanced intermediate related to the natural product (-)-alpha-kainic acid.

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收藏

页码：2111 / 2119

页数：9

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