Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits

被引：65

作者：

Walley, AJ ^{[1
]}

Wiltshire, S ^{[1
]}

Ellis, CM ^{[1
]}

Cookson, WOCM ^{[1
]}

机构：

[1] Wellcome Ctr Human Genet, Asthma Genet Grp, Oxford OX3 7BN, England

来源：

GENOMICS | 2001年 / 72卷 / 01期

关键词：

D O I：

10.1006/geno.2000.6435

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Linkage and association of polymorphic markers in the chromosome 5q31-q33 cytokine cluster to atopy and asthma associated phenotypes have been reported by a number of groups. To investigate this region, 29 polymorphic markers were used to genotype a combined set of 233 families. These markers were ordered based upon the genetic data, supplemented by published genetic and physical maps. Significant two-point linkage was observed for asthma (most significant marker IRF1, P = 0.0002) and atopy (CD14SNP, P = 0.0001). Allelic association was observed between D5S463 and atopy (P = 0.002) and the skin prick test index (P = 0.04). The data support the possibility of three asthma/atopy loci in the 5q31-q33 region, each with a relatively small effect. (C) 2001 Academic Press.

引用

页码：15 / 20

页数：6

共 39 条

[1] A general test of association for quantitative traits in nuclear families [J].

Abecasis, GR ;

Cardon, LR ;

Cookson, WOC .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 66 (01) :279-292

[2] GENERAL METHOD FOR ISOLATION OF HIGH MOLECULAR-WEIGHT DNA FROM EUKARYOTES [J].

BLIN, N ;

STAFFORD, DW .

NUCLEIC ACIDS RESEARCH, 1976, 3 (09) :2303-2308

[3] Absence of linkage between 5q markers and serum IgE levels in four large atopic families [J].

Blumenthal, MN ;

Wang, Z ;

Weber, JL ;

Rich, SS .

CLINICAL AND EXPERIMENTAL ALLERGY, 1996, 26 (08) :892-896

[4] Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome [J].

Chavanas, S ;

Bodemer, C ;

Rochat, A ;

Hamel-Teillac, D ;

Ali, M ;

Irvine, AD ;

Bonafé, JL ;

Wilkinson, J ;

Taïeb, A ;

Barrandon, Y ;

Harper, JI ;

de Prost, Y ;

Hovnanian, A .

NATURE GENETICS, 2000, 25 (02) :141-142

[5]

COOKSON WOCM, 1988, LANCET, V1, P86

[6] Association of persistent bronchial hyperresponsiveness with β2-adrenoceptor (ADRB2) haplotypes -: A population study [J].

D'Amato, M ;

Vitiani, LR ;

Petrelli, G ;

Ferrigno, L ;

di Pietro, A ;

Trezza, R ;

Matricardi, PM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 158 (06) :1968-1973

[7] A genome-wide search for quantitative trait loci underlying asthma [J].

Daniels, SE ;

Bhattacharrya, S ;

James, A ;

Leaves, NI ;

Young, A ;

Hill, MR ;

Faux, JA ;

Ryan, GF ;

leSouef, PN ;

Lathrop, GM ;

Musk, AW ;

Cookson, WOCM .

NATURE, 1996, 383 (6597) :247-250

[8] The glutamine 27 beta(2)-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families [J].

Dewar, JC ;

Wilkinson, J ;

Wheatley, A ;

Thomas, NS ;

Doull, I ;

Morton, N ;

Lio, P ;

Harvey, JF ;

Liggett, SB ;

Holgate, ST ;

Hall, IP .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 100 (02) :261-265

[9] A comprehensive genetic map of the human genome based on 5,264 microsatellites [J].

Dib, C ;

Faure, S ;

Fizames, C ;

Samson, D ;

Drouot, N ;

Vignal, A ;

Millasseau, P ;

Marc, S ;

Hazan, J ;

Seboun, E ;

Lathrop, M ;

Gyapay, G ;

Morissette, J ;

Weissenbach, J .

NATURE, 1996, 380 (6570) :152-154

[10] Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness [J].

Doull, IJM ;

Lawrence, S ;

Watson, M ;

Begishvili, T ;

Beasley, RW ;

Lampe, F ;

Holgate, ST ;

Morton, NE .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (04) :1280-1284

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