Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits

被引：65

作者：

Walley, AJ ^{[1
]}

Wiltshire, S ^{[1
]}

Ellis, CM ^{[1
]}

Cookson, WOCM ^{[1
]}

机构：

[1] Wellcome Ctr Human Genet, Asthma Genet Grp, Oxford OX3 7BN, England

来源：

GENOMICS | 2001年 / 72卷 / 01期

关键词：

D O I：

10.1006/geno.2000.6435

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Linkage and association of polymorphic markers in the chromosome 5q31-q33 cytokine cluster to atopy and asthma associated phenotypes have been reported by a number of groups. To investigate this region, 29 polymorphic markers were used to genotype a combined set of 233 families. These markers were ordered based upon the genetic data, supplemented by published genetic and physical maps. Significant two-point linkage was observed for asthma (most significant marker IRF1, P = 0.0002) and atopy (CD14SNP, P = 0.0001). Allelic association was observed between D5S463 and atopy (P = 0.002) and the skin prick test index (P = 0.04). The data support the possibility of three asthma/atopy loci in the 5q31-q33 region, each with a relatively small effect. (C) 2001 Academic Press.

引用

页码：15 / 20

页数：6

共 39 条

[11]

Hobart M, 1997, J IMMUNOL, V158, P4260

[12]

HOLROYD KJ, 1998, AM J RESP CRIT CARE, V157, pA773

[13] Integrated physical and transcript map of 5q31.3-qter [J].

Kostrzewa, M ;

Krings, BW ;

Dixon, MJ ;

Eppelt, K ;

Köhler, A ;

Grady, DL ;

Steinberger, D ;

Fairweather, ND ;

Moyzis, RK ;

Monaco, AP ;

Müller, U .

EUROPEAN JOURNAL OF HUMAN GENETICS, 1998, 6 (03) :266-274

[14] COMPLEMENTARY-DNA CLONING OF THE MAJOR ALLERGEN PHL-P-I FROM TIMOTHY GRASS (PHLEUM-PRATENSE) - RECOMBINANT PHL-P-I INHIBITS IGE BINDING TO GROUP-I ALLERGENS FROM 8 DIFFERENT GRASS SPECIES [J].

LAFFER, S ;

VALENTA, R ;

VRTALA, S ;

SUSANI, M ;

VANREE, R ;

KRAFT, D ;

SCHEINER, O ;

DUCHENE, M .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1994, 94 (04) :689-698

[15] Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population [J].

Laitinen, T ;

Kauppi, P ;

Ignatius, J ;

Ruotsalainen, T ;

Daly, MJ ;

Kaariainen, H ;

Kruglyak, L ;

Laitinen, H ;

delaChapelle, A ;

Lander, ES ;

Laitinen, LA ;

Kere, J .

HUMAN MOLECULAR GENETICS, 1997, 6 (12) :2069-2076

[16] STRATEGIES FOR MULTILOCUS LINKAGE ANALYSIS IN HUMANS [J].

LATHROP, GM ;

LALOUEL, JM ;

JULIER, C ;

OTT, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (11) :3443-3446

[17] A first trial of retrospective collaboration for positional cloning in complex inheritance: Assay of the cytokine region on chromosome 5 by the Consortium on Asthma Genetics (COAG) [J].

Lonjou, C ;

Barnes, K ;

Chen, H ;

Cookson, WOCM ;

Deichmann, KA ;

Hall, IP ;

Holloway, JW ;

Laitinen, T ;

Palmer, LJ ;

Wjst, M ;

Morton, NE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (20) :10942-10947

[18]

Mansur AH, 1998, CLIN EXP ALLERGY, V28, P141

[19]

Marsh DG, 1997, NAT GENET, V15, P389

[20] LINKAGE ANALYSIS OF IL4 AND OTHER CHROMOSOME 5Q31.1 MARKERS AND TOTAL SERUM IMMUNOGLOBULIN-E CONCENTRATIONS [J].

MARSH, DG ;

NEELY, JD ;

BREAZEALE, DR ;

GHOSH, B ;

FREIDHOFF, LR ;

EHRLICHKAUTZKY, E ;

SCHOU, C ;

KRISHNASWAMY, G ;

BEATY, TH .

SCIENCE, 1994, 264 (5162) :1152-1156

← 1 2 3 4 →