Decoding the dynamics of T cell-dendritic cell interactions in vivo

被引：40

作者：

Celli, Susanna ^{[1
,2
]}

Garcia, Zacarias ^{[1
,2
]}

Beuneu, Helene ^{[1
,2
]}

Bousso, Philippe ^{[1
,2
]}

机构：

[1] Inst Pasteur, Dept Immunol, Equipe Avenir Inserm U 668, G5 Dynam Reponses Immunes, F-75015 Paris, France

[2] Equipe Avenir, Inserm U 668, Paris, France

来源：

IMMUNOLOGICAL REVIEWS | 2008年 / 221卷

关键词：

Tcell; dendritic cell; imaging; lymph node;

D O I：

10.1111/j.1600-065X.2008.00588.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T lymphocytes receive activation signals during their encounters with antigen-bearing dendritic cells (DCs) in secondary lymphoid organs. With the recent application of two-photon imaging to visualize immune responses as they happen, the dynamics of T cell-DC interactions have been dissected in several mouse models. As we are integrating the results of these new studies, we are learning that the dynamics of T cell-DC interactions are regulated by multiple immunological parameters and, most importantly, that the spatiotemporal characteristics of these cell-cell contacts encode part of the T-cell fate.

引用

收藏

页码：182 / 187

页数：6

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