A simple, two-step synthesis of 3-iodoindoles

被引：146

作者：

Amjad, M ^{[1
]}

Knight, DW ^{[1
]}

机构：

[1] Cardiff Univ, Cardiff Sch Chem, Cardiff CF10 3TB, S Glam, Wales

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 03期

关键词：

5-endo-dig; iodocyclisation; sonogashira; indole; synthesis;

D O I：

10.1016/j.tetlet.2003.10.207

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Halo-anilines, protected as the corresponding sulfonamides or carbamates, can be converted very efficiently into 3-iodoindoles by sequential Sonogashira coupling with a 1-alkyne and 5-endo-dig iodocyclisation. Azaindoles can also be obtained using this methodology. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：539 / 541

页数：3

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