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Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis
被引:277
作者:
de Vries, SS
Baart, EB
Dekker, M
Siezen, A
de Rooij, DG
de Boer, P
te Riele, H
[1
]
机构:
[1] Wageningen Inst Anim Sci, Lab Genet, NL-6709 PG Wageningen, Netherlands
[2] Univ Utrecht, Sch Med, Dept Cell Biol, Utrecht, Netherlands
[3] Netherlands Canc Inst, Div Mol Carcinogensis, NL-1066 CX Amsterdam, Netherlands
关键词:
meiosis;
recombination;
mismatch repair;
synapsis;
mouse;
D O I:
10.1101/gad.13.5.523
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Members of the mammalian mismatch repair protein family of MutS and MutL homologs have been implicated in postreplicative mismatch correction and chromosome interactions during meiotic recombination. Here we demonstrate that mice carrying a disruption in Mut5 homolog Msh5 show a meiotic defect, leading to male and female sterility. Histological and cytological examination of prophase I stages in both sexes revealed an extended zygotene stage, characterized by impaired and aberrant chromosome synapsis, that was followed by apoptotic cell death. Thus, murine Msh5 promotes synapsis of homologous chromosomes in meiotic prophase I.
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页码:523 / 531
页数:9
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