The sleep switch: hypothalamic control of sleep and wakefulness

被引：1046

作者：

Saper, CB ^{[1
]}

Chou, TC

Scammell, TE

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Program Neurosci, Boston, MA 02215 USA

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 12期

关键词：

D O I：

10.1016/S0166-2236(00)02002-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

More than 70 years ago, von Economo predicted a wake-promoting area in the posterior hypothalamus and a sleep-promoting region in the preoptic area. Recent studies have dramatically confirmed these predictions. The ventrolateral preoptic nucleus contains GABAergic and galaninergic neurons that are active during sleep and are necessary for normal sleep. The posterior lateral hypothalamus contains orexin/hypocretin neurons that are crucial for maintaining normal wakefulness. A model is proposed in which wake-and sleep-promoting neurons inhibit each other, which results in stable wakefulness and sleep. Disruption of wake-or sleep-promoting pathways results in behavioral state instability.

引用

页码：726 / 731

页数：6

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