Regulation and organization of adenylyl cyclases and cAMP

被引：257

作者：

Cooper, DMF ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1PD, England

来源：

BIOCHEMICAL JOURNAL | 2003年 / 375卷

关键词：

adenylyl cyclase; calcium; cAMP; G-protein; protein kinase A (PKA); raft;

D O I：

10.1042/BJ20031061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenylyl cyclases are a critically important family of multiply regulated signalling molecules. Their susceptibility to many modes of regulation allows them to integrate the activities of a variety of signalling pathways. However, this property brings with it the problem of imparting specificity and discrimination. Recent studies are revealing the range of strategies utilized by the cyclases to solve this problem. Microdomains are a consequence of these solutions, in which cAMP dynamics may differ from the broad cytosol. Currently evolving methodologies are beginning to reveal cAMP fluctuations in these various compartments.

引用

页码：517 / 529

页数：13

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